They require a large compressor. Also, if you are concerned with hooking it up to a vac for dust control, it makes since to just go with an electric. I much prefer a 5" dynabrade to 6" electric hooked up to a vacuum, but my shop and my lungs are much cleaner with a vacuum.
That and they usually top out around the 5" mark and lack dust control for the most part.
I loved my jitterbugs when I was making doors for a living but I also was doing so in a climate controlled spray room that had some great dust collection and some pretty huge air compressors and tanks. In a home shop you will dust blow yourself out of the room without some proper dust collection at the sander. Not many air sanders I have seen support that.