If using Draino crystals, realize that it is sodium hydroxide (lye), a very strong alkalie, and if gotten in your eyes can cause a permanent and progressing loss of eyesight,(Use eye protection, gloves, and have a bucket of clean water handy to rinse off any body parts that come in contact with it). This is the same stuff that they used to use in slaughter houses to dissolve all the scrap hide, bones, etc. If it spills in the yard, don't expect much to grow there for a couple of years. It also will dissolve aluminum.
It is very good for removing grease and rust from iron/steel. In another life, we used a 1000 gal tank to dip maintenance stands to strip off all the paint and clean the rust in one operation (doesn't work on epoxy or polyurethane, tho)
A acidic solution is the neutralizer, so having a jug of vinegar handy wouldn't be a bad idea to neutralize spills or splashes.
Oh yeah, if you use a natural bristle brush, it will probably dissolve the bristles.
Do not mix it with bleach. Doing so can liberate phosgene, chlorine and possibly flourine gas, all deadly and two are odorless.
Enough with the cautions. It is a good chemical with a lot of positive uses but be careful with it.