Just dogs, a single 5/8 is fine. My old Workmate has 5/8 ply as tops and plastic dogs. Works fine for 25+ years. OK, it is an old one with birch ply, not MDF. I guess it depends on the style of dog. I have cylinders about 3 inches long with no flange so their height is adjustable. They need a thicker top for them to work so the spring contacts the side. I have some aluminum ones with a 3/8 top button so they would work fine in a 5/8 top. Then a pile of various plastic ones, all would work in a 5/8th.
How stable depends on the hole size. As I have discovered, 3/4, 19, 20, 21, 22mm depending on brand. And then there are various DIY round and square dogs which are up to your imagination.
Hold-fasts and other clamp down devices are another story. My outfeed had double 5/8 MDF and works fine with the lever and screw hold-downs, but a hold-fast would tear it apart. My heavy bench is 5 inches SYP and holdfasts work quite well. Yea, overkill but it does not wiggle.